Big Mouth spares no gross detail as it delves into the fraught world of adolescence and all the rages, bodily fluids, and knee-jerk masturbatory instincts it brings. Adding yet another layer of weirdness is that Big Mouth personifies puberty by way of opposing “hormone monsters,” with the lecherous Maury (series co-creator Nick Kroll) following meek Andrew (John Mulaney) as he frets his way through his new urges, while curvaceous Connie (Maya Rudolph) tags alongside Jessi (Jessi Klein) to prod her into indulging in vicious mood swings.